Extraction studies of Tabernanthe iboga and Voacanga africana.

Indole alkaloids from cell suspension cultures of Stemmadenia tomentosa and Voacanga africana.

Stemmadenia tomentosa var. palmeri, Voacanga africana, Apocynaceae, Cell Suspension Cultures, Indole Alkaloids Cell suspension cultures of Stemmadenia tomentosa synthesized under normal growth condition the eight major indole alkaloids: (-)-tabersonine, (—)-minovincinine, (+)-conoflorine (voaphylline), condylocarpine, (+)-tubotaiwine (dihydrocondylocarpine), (-)-norfluorocurarine (vincanine), (...

Iboga and Ibogaine

Antioxidant and Anti-inflammatory Properties of a Flavonoid Fraction from the Leaves of Voacanga Africana

In this study we used several models for evaluation of probable anti-inflammatory and antinociceptive effects of the flavonoid fraction of the leaves of Voacanga africana, using mice and rats. The extract (50 150mg/kg, p.o) inhibited, in a dose-related manner, carrageenan induced paw oedema in rats. The extract caused a significant inhibition of the cotton-pellet granuloma. Vascular permeabilit...

The hydroxyindolenine derivative of voacangine, a new indole alkaloid from Voacanga africana.

A new alkaloid from Voacanga africana was identified as the hydtoxyindolenine derivative (6) of voacangine, and its structure was proven hy synthesis. A rearrangement product of 6, the pseudoindoxyl9, was also encountered and characterized. Two additional new alkaloids, the hydroxyindolenine (7) and pseudoindoxyl (10) derivatives of voacristine were synthesized. Mass spectra of all compounds ar...

The near-death experience: a cerebellar method to protect body and soul-lessons from the Iboga healing ceremony in Gabon.

The root bark of the Iboga shrub (Tabernanthe iboga) is used in Gabon, Africa, to induce a near-death experience for spiritual and psychological purposes. The pharmacology of ibogaine, a psychoactive indole alkaloid extracted from the bark, has been investigated extensively because of its putative qualities to treat addiction. This review of these studies and neuroscientific approaches to the n...